Welcome to the modern Holiday Inn Express & Suites just off of Interstate 55 at the Butler Hill Road intersection! Enjoy our Midwest hospitality with an array of amenities including guest room suites, indoor pool, complimentary breakfast, complimentary high speed Internet and cookies and milk served nightly. Be sure to explore all that St. Louis has to offer including Busch Stadium, Gateway Arch, Grant’s Farm, Magic House, St. Louis Science Center, St. Louis Zoo, Forest Park and more! Interested? Please download our E-brochure.


Our hotels are taking applications! Click the button below to start the online application process.

Contact and Reservations

  • Phone: 314-894-0700
  • Fax: 314-894-0167
  • Address: 4250 Midamerica Ln., Saint Louis, MO 63129


  • Twenty-four hour business center
  • Complimentary wired and wireless Internet Access
  • On-site health and fitness center
  • Indoor pool and whirlpool
  • On-site washer and dryer
  • Daily housekeeping
  • Dry cleaning pick-up/laundry
  • Same day dry cleaning
  • Hot breakfast served daily
  • Ice machine
  • Safe deposit box (located at the front desk)
  • Complimentary milk and cookies, served in lobby during the evening


Planning a meeting or gathering in the Saint Louis area? Consider the Jefferson Room or Mississippi Room at Holiday Inn Express and Suites, Saint Louis.

Jefferson Room

The Jefferson Room, located on the first room of the hotel, offers complimentary wireless Internet, an 80 inch television, a water station, and more.

  • 330 sq. foot Meeting Space (13′ x 37′)
  • 80″ TV with VGA/HDMI connection
  • Speakers/PA for A/V connection to TV
  • Water station
  • Wireless Internet access
  • Hardwired Internet access for one computer
  • Seating Specifications: 18 theatre, 12 classroom, 16 boardroom, 12 U-shape

Mississippi Room

The Mississippi Room is available to book after 11:00 A.M and is located on the first floor of the hotel.

  • 345 sq. ft space (13′ x 27′)
  • 12 boardroom seats

Please contact our sales team at 314-894-0700 for more details.

Pet Policy

  • Pets are not allowed at this property.
  • Service animals allowed.

Reviews and Rewards

Awards and Recognition

  • 2019 IHG Quality Excellence Award
  • 2019 Trip Advisor Certificate of Excellence
  • 2018 IHG Newcomer Award
  • Booking.com Guest Reviews Awards – 2018