This beautiful hotel is conveniently located just off of Interstate 55 in Cape Girardeau and is surrounded by many restaurants. The Hampton Inn features complimentary hot breakfast daily and free high-speed Internet access. Take a relaxing swim in our heated pool and join us in the evening for complimentary cookies and milk. Interested? Please download our E-brochure


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Contact and Reservations

  • Phone: 573-334-4499
  • Fax: 573-334-5100
  • Address: 207 S. Mount Auburn, Cape Girardeau, MO 63703


  • Twenty-four hour business center
  • Complimentary wired and wireless Internet Access
  • On-site health and fitness center
  • Indoor heated pool
  • On-site washer and dryer
  • Daily housekeeping
  • Dry cleaning pick-up/laundry
  • Same day dry cleaning
  • Hot breakfast served daily
  • Service animals allowed
  • No pets allowed
  • Ice machine
  • Safe deposit box (located at the front desk)
  • Complimentary milk and cookies, served in lobby during the evening


Auburn Room

Planning a meeting or gathering in Cape Girardeau, MO? Hampton Inn offers the Auburn Room for your consideration. The Auburn Room includes the following features:

● 776 sq. foot meeting space (33′ x 23′ x 8.5′) ● Free Wi-Fi ● Automated retractable screen (6’x 8′) ● LCD projector ● Sound system ● 8′ x 1.5′ tables ● Seating Specifications: 36 Classroom, 28 Conference, 48 Banquet (no rounds), 50 Theatre, 24 U-Shape, 28 H-Square

Please contact our sales team at 573-334-4499 for more details.

Pet Policy

  • Pets are not allowed at this property.
  • Service animals allowed.

Reviews and Rewards

Awards and Recognition

  • 2018 Conrad Hilton ‘Connie’ Award
  • 2017 Conrad Hilton ‘Connie’ Award
  • 2016 Conrad Hilton ‘Connie’ Award