Holiday Inn Express & Suites Cape Girardeau is located right off of Interstate 55 and is centered in the middle of several dining and shopping venues within walking distance. The beautiful 102 room hotel features complimentary hot breakfast, free high-speed Internet access and complimentary cookies and milk each evening. Interested? Please download our E-brochure.


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Contact and Reservations

  • Phone: 573-334-4491
  • Fax: 573-334-4261
  • Address: 3253 William Street, Cape Girardeau, MO 63701


  • Twenty-four hour business center
  • Complimentary wired and wireless Internet Access
  • On-site health and fitness center
  • Indoor pool and whirlpool
  • On-site washer and dryer
  • Daily housekeeping
  • Dry cleaning pick-up/laundry
  • Same day dry cleaning
  • Hot breakfast served daily
  • Ice machine
  • Safe deposit box (located at the front desk)
  • Complimentary milk and cookies, served in lobby during the evening


Planning a meeting or gathering in Cape Girardeau, MO? Holiday Inn Express and Suites offers the Lorimier Room and LaSalle Room your consideration.

Lorimier Room

The Holiday Inn Express & Suites Cape Girardeau offers a great space fit for your next event. The Lorimier Room is located on the ground level and features a bar prep area with sink and microwave.

● 120 sq. foot Meeting Space (20′ x 6′) ● 30′ high ceiling ● Free Wi-Fi ● A/V equipment rental available ● Seating Specifications: 35 Classroom, 30 Boardroom, 25 Banquet, 25 Reception, 30 Theatre, 30 U-Shape, 30 H-Square

LaSalle Room

We also offer a spacious boardroom perfect for meetings. The LaSalle is located on the second floor of the hotel and features natural light with big windows, and one that overlooks the beautiful lobby.

● Boardroom style seating for 8 ● Free Wi-Fi

Please contact our sales team at 573-334-4491 for more details.

Pet Policy

  • Pets are not allowed at this property.
  • Service animals allowed.

Reviews and Rewards

Awards and Recognition

  • 2019 IHG Quality Excellence Award
  • 2018 IHG Torchbearer Award
  • 2017 IHG Torchbearer Award
  • 2016 IHG Torchbearer Award
  • 2015 IHG Torchbearer Award
  • 2014 IHG Torchbearer Award
  • 2013 IHG Torchbearer Award
  • 2012 IHG Torchbearer Award
  • 2011 IHG Quality Excellence Award
  • 2010 IHG Quality Excellence Award
  • 2009 IHG Quality Excellence Award
  • 2008 IHG Torchbearer Award
  • 2007 IHG Quality Excellence Award
  • 2006 IHG Newcomer of the Year