• Holiday Inn Express & Suites Cape Girardeau is located right off Interstate 55 at exit 96. We offer spacious guest rooms and many amenities to fit your hotel needs such as complimentary hot breakfast and free high-speed Internet access. Our accommodating staff will be happy to assist with any of your hotels needs.

    Holiday Inn Express & Suites, Cape Giradeau
  • : 3253 William Street, Cape Girardeau, MO 63701
  • : 573-334-4491
  • : 573-334-4261

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